Adding a certain compound to certain chemical reactions, such as: 713-41-7, name is 2-Amino-4-(trifluoromethyl)benzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 713-41-7, Quality Control of 2-Amino-4-(trifluoromethyl)benzamide
Production Example 3 (1) 0753] A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 813 mg of 2-ethylsulfanylbenzaldehyde, 764 mg of sodium bisulfite and 4 ml of DMA was stirred at 150C for 8 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.49 g of 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4 -one. 2-(2-Ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinaz olin-4-one [0754] 1H-NMR(CDCl3)delta: 10.46(1H, brs), 8.43(1H, d), 8.11(1H, s), 7.91(1H, dd),7.72(1H, dd), 7.54 (1H, dd),7.50(1H, td), 7.41(1H, td), 2.92(2H, q), 1.28(3H, t).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-4-(trifluoromethyl)benzamide, and friends who are interested can also refer to it.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; TAKAHASHI, Masaki; ITO, Mai; NOKURA, Yoshihiko; TANABE, Takamasa; SHIMIZU, Chie; EP2865671; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics