In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5202-85-7 as follows. Product Details of 5202-85-7
General procedure: Indiumtribromide (0.5 mol %) was added to a solution of 2-amino benzanilide or 2-amino-5-chloro benzamide (1 mmol) and desired aldehydes (1 mmol) in acetonitrile (3mL). The mixture was stirred at room temperature for the specified period of time. The progress of the reaction was monitored by TLC. After completion of reaction, solvent was evaporated at reduced pressure, and solid was partitioned between ethyl acetate (15.0 mL) and water (15.0mL), and transferred to a separatory funnel. The organic layer was washed with water, and brine, dried over anhydrous Na2SO4 (s) and concentrated in vacuo. The residue was purified by recrystallization from CH2Cl2/Hexane to afford the corresponding pure 2,3-dihydroquinazolin-4(1H)-ones (3a-3aa) as solids with excellent yields.
According to the analysis of related databases, 5202-85-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Rajaka, Lingayya; Penumati, Nageshwar Rao; Nagaiah; Poornachandra; Kumar, C. Ganesh; Synthetic Communications; vol. 45; 16; (2015); p. 1893 – 1901;,
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