Reference of 88-96-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88-96-0 name is Phthalamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1) Synthesis of phthalimide potassium A round-bottom flask containing 3200 mL dehydrated alcohol was added with 160.0 g phthalamide, and heated and refluxed for 0.5 h, until only a small amount of raw materials was not dissolved. The resulted hot solution was added into 61.0 g potassium hydroxide solution (including 60 mL water and 180 mL alcohol) by decantation, by which a white precipitate was formed immediately. Then the solution was cooled and filtered to obtain filtered residue, and alcohol was recycled. The filtered residue was washed with 400 mL acetone, 196.0 g phthalimide potassium was obtained, and the yield was 98.0%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Phthalamide, and friends who are interested can also refer to it.
Reference:
Patent; Institue of Transfusion Medicine, Academy of Military Medical Sciences, People’s Liberation Army of China; PEI, Xuetao; LI, Yanhua; WANG, Sihan; ZHANG, Jing; YAO, Hailei; SHI, Wei; YUE, Wen; EP2949323; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics