Related Products of 144-80-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 144-80-9 as follows.
Example 155N-({4-[(4-[difluoro(4-fluorophenyl)methyl]-6-{[6-(ethyloxy)-1,3-benzothiazol-2-yl]amino}-2-pyrimidinyl)amino]phenyl}sulfonyl)acetamideA mixture of N-{2-chloro-6-[difluoro(4-fluorophenyl)methyl]-4-pyrimidinyl}-6-(ethyloxy)-1,3-benzothiazol-2-amine (100mg, 0.222mmol), N-[(4-aminophenyl)sulfonyl]acetamide (95mg, 0.444mmol) and 4-toluenesulfonic acid monohydrate (50.6mg, 0.266mmol) in acetonitrile (3m L) was sealed and heated at 1200C for 4 hours in a Biotage “Initiator” microwave. The product was purified by mass-directed autopreparative HPLC (formic acid modifier) to afford the title compound (21 rmg, 0.033mmol, 20% yield) as a white solid. LCMS (Method A): Rt 1.19 minutes; m/z 629 (MH+).
According to the analysis of related databases, 144-80-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; ALDER, Catherine, Mary; BALDWIN, Ian, Robert; BARTON, Nicholas, Paul; CAMPBELL, Amanda, Jennifer; CHAMPIGNY, Aurelie, Cecile; HARLING, John, David; MAXWELL, Aoife, Caitriona; SIMPSON, Juliet, Kay; SMITH, Ian, Edward, David; TAME, Christopher, John; WILSON, Caroline; WOOLVEN, James, Michael; WO2010/106016; (2010); A1;,
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