Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2896-98-2, name is Tetrahydro-1,4-thiazepan-5-one, A new synthetic method of this compound is introduced below., SDS of cas: 2896-98-2
To a solution of 1,4-thiazepan-5-one (3.0 g) in distilled THF (90 mL) cooled to 0 C. is added dropwise a solution of LiAlH4 in THF (1M solution, 22.9 mL). The mixture is stirred at room temperature for 2 h. The reaction is quenched by successive addition of water (2 mL), 15% NaOH (2 mL) and water (2 mL). The reaction mixture is filtered to remove the aluminum salt that had precipitated. The filtrate was dried (Na2SO4), filtered, and concentrated to obtain 2.63 g (98%) of 1,4-thiazepane as a yellow residue. Physical characteristics are as follows: 1H NMR (300 MHz, CDCl3) delta3.07, 2.96, 2.75, 1.92.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Pharmacia & Upjohn Company; US6248739; (2001); B1;,
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