In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of tert-Butyl methyl(2-(methylamino)ethyl)carbamate
Brought 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione (1-3) (500 mg, 1.81 mmol) , tert-butyl methyl(2-(methylamino)ethyl)carbamate (22-1) (1.99 mmol) and DIEA (787 4.52 mmol) up in NMP (3.62 mL ) and heated to 90°C overnight. Cooled the mixture to r.t. and loaded directly onto reversed phase isco 10-100percent ACN/water w TFA. Lyophilized the combined fractions to give tert-butyl (2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4- yl)(methyl)amino)ethyl)(methyl)carbamate (800 mg, 1.79 mmol, 99.5 percent) as a yellow solid. LC/MS (ES+): m/z 467 [M+Na]+
The synthetic route of 112257-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
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