In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35303-76-5 as follows. name: 4-(2-Aminoethyl)benzenesulfonamide
To solid reagents 4-(2-aminoethyl)benzenesulfonamide (2.00 g, 9.99 mmol) and dihydrofuran-2,5-dione (0.999 g, 9.99 mmol) was added THF (30 mL). The reaction mixture was stirred at 60 C for 7 hrs. Solvent was evaporated under reduced pressure to give 4-oxo-4-((4- sulfamoylphenethyl)amino)butanoic acid (3.00 g, 9.99 mmol, 100 % yield) as a white solid.1H NMR (400 MHz, DMSO-d6) delta 12.09 (s, 1H), 7.96 (t, J = 5.6 Hz, 1H), 7.72 (d, J = 8.1 Hz, 2H), 7.38 (d, J = 8.1 Hz, 2H), 7.29 (s, 2H), 3.26 (q, J = 6.8 Hz, 2H), 2.76 (t, J = 7.2 Hz, 2H), 2.40 (t, J = 6.9 Hz, 2H), 2.27 (t, J = 6.9 Hz, 2H); MS (ESI), 301.1 (M+H)+.
According to the analysis of related databases, 35303-76-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WAVE LIFE SCIENCES LTD.; ZHANG, Jason Jingxin; SHIVALILA, Chikdu Shakti; VARGEESE, Chandra; IWAMOTO, Naoki; (469 pag.)WO2019/75357; (2019); A1;,
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