Some common heterocyclic compound, 1103234-56-5, name is 2,6-Difluoro-3-(propylsulfonamido)benzoic acid, molecular formula is C10H11F2NO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1103234-56-5
Example- 1 Preparation of 3-(Propane-l -sulfonylamino)-benzoyl chloride (IotaPi) Charge 2, 6-difiuoro-3-(((propan-l-yl) sulphonyl) amino) benzoic acid (5gm, 0.018 mol) was charged in to a reaction flask at 2S-30Ccontaining Toluene (25ml) under nitrogen atmosphere. Reaction mass was cooled to 10-15C. Thionyl chloride (15ml, 0.077mol) was added drop wise to mass at 10-15C and stirred for 15min. Reaction mass allowed to warm 25-30C and stirred for 30min. Heated the reaction mass to 105-110C and stirred for 4 hrs. Reaction mass cooled to 55-60C and organic volatiles distilled off completely to get semisolid residue and as such used in-situ for next stage.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1103234-56-5, its application will become more common.
Reference:
Patent; SHILPA MEDICARE LIMITED; PUROHIT, Prashant; NAGNNATH, Kokare; YENIREDDY, Veera Reddy; AKSHAY KANT, Chaturvedi; (0 pag.)WO2016/83956; (2016); A1;,
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