Some common heterocyclic compound, 127-77-5, name is 4-Amino-N-phenylbenzenesulfonamide, molecular formula is C12H12N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C12H12N2O2S
To a well-stirred solution of compound 2 (2.48 g, 0.01 mol) inchloroform, benzoyl chloride (1.28 ml, 0.011 mol) in chloroformwas added dropwise at 0 C and stirring was continued in cold condition.After the completion of reaction (monitored by TLC), thereaction mixture was poured into ice cold water. White solid wasfiltered, washed with acetic acid and sodium bicarbonate solutions,dried and purified by recrystallization. Single crystals suitable fordiffraction studies were obtained by slow evaporation fromethanol.Analytical and physical data: Formula: C19H16N2O3S; Yield:70-75%; LCMS (+ve mode): (M + H) = 353.0 (99.5%), RT – 4.349;HRMS: Obtained m/z = 375.0777 (M + Na), cald. = 375.0779.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 127-77-5, its application will become more common.
Reference:
Article; Lahtinen, Manu; Kudva, Jyothi; Hegde, Poornima; Bhat, Krishna; Kolehmainen, Erkki; Nonappa; Venkatesh; Naral, Damodara; Journal of Molecular Structure; vol. 1060; 1; (2014); p. 280 – 290;,
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