Reference of 326-67-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 326-67-0 as follows.
Chlorosulfonic acid (20.56 g, 176.46 mmol, 5 equiv.) was slowly added to N-(2-fluoro-4-methylphenyl) acetamide (5.90 g,35.29 mmol, 1 equiv.) keeping the temperature of the reactionmixture below 50 C. The resulting mixture was then heated to70 C for 4 hours. After cooling to room temperature, thereaction mixture was then poured carefully into ice, the precipitate was filtered, washed well with distilled water and dried to get 7.3 g of crude product as light brown solid. The crude product thus obtained was further used as such without any purification.?H NMR (CDC13) : 6 9.09 (d, J = 7.6 Hz, 1H), 7.48 (bs, 1H), 7.14 (d, J = 10.8 Hz, 1H) , 2.72 (s, 3H) , 2.25 (s, 3H)
According to the analysis of related databases, 326-67-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INSECTICIDES (INDIA) LIMITED; OAT AGRIO CO., LTD; IMAI, Tetsuya; KUMAWAT, Surendra Kumar; SINGH, Manish Kumar; CHAUHAN, Pramod Kumar; SHELKE, Amol Vasant; SINGH, Rajesh Kumar; KISHORE, Ram; BHATT, Ashish; (97 pag.)WO2018/15852; (2018); A1;,
Amide – Wikipedia,
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