Electric Literature of 16982-21-1, These common heterocyclic compound, 16982-21-1, name is Ethyl 2-amino-2-thioxoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2-bromo-1-(4-nitrophenyl)ethanone(9.2 g, 37.7 mmol, 1.0 equiv) in methanol (200 ml) was added ethyl 2-amino-2-thioxoacetate (5.0 g, 37.7 mmol, 1.0 equiv) and reaction mixture was refluxed for 2 h. Following reaction completion the reaction mass was cooled to rt and the precipitated solid was filtered, washed with cold methanol, and dried to yield (7.1 g, 67%)of the title compound as a white solid.
The synthetic route of 16982-21-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kadam, Kishorkumar S.; Jadhav, Ravindra D.; Kandre, Shivaji; Guha, Tandra; Reddy, M. Mahesh Kumar; Brahma, Manoja K.; Deshmukh, Nitin J.; Dixit, Amol; Doshi, Lalit; Srinivasan, Shaila; Devle, Jayendra; Damre, Anagha; Nemmani, Kumar V. S.; Gupte, Amol; Sharma, Rajiv; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 337 – 347;,
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