Adding a certain compound to certain chemical reactions, such as: 94838-59-2, name is tert-Butyl 4-aminophenethylcarbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94838-59-2, Quality Control of tert-Butyl 4-aminophenethylcarbamate
2-(1,3-dioxo-2Hisoindol-2-yl)-4- thiazolylacetic acid(Formula 3-1) (CAS No. 954268-27-0) (20.0 g, 0.069 mole) and Hydroxybenzotriazole hydrate (11.9 g, 0.077 mole) was dissolved in dichloromethane (160 ml), and then cooled to 0 to 5 C. N, N-dicyclohexylcarbodiimide (14.3 g, 0.069 mole) was dissolved in dichloromethane (40 ml) and slowly added dropwise to the cooled mixture, and then Maintaining temperature at 0 ~ 5 and stirred for 30 min. To the suspended reaction solution [2- (4-aminophenyl) Ethyl] carbamic acid tert-butyl ester (Formula 2-1) (CAS No. 94838-59-2) (16.4 g, 0.069 mole) and Triethylamine (7.02 g, 0.069 mole) was added thereto and stirred at room temperature (20 to 25 C) for 24 hours. After completion of the reaction, the reaction solution was cooled to 0 to 5 C, stirred for 12 hours, and filtered. After filtration, the residue was washed with dichloromethane (20 ml), and the filtrate was obtained. The residue was extracted with 200 ml of brine solution. The extraction was carried out three times. An organic layer was obtained, and the solid obtained by concentration under reduced pressure at 35 to 40 C was vacuum-dried at 35 to 40 C for 15 hours to obtain the compound of Formula 5-1 (30.5 g, yield 87%).
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Reference:
Patent; Nebular Perm Nosebleed A Co., Ltd.; Jeong In-hwa; Lee In-gyu; Mo Gil-ung; Han Hae-su; Han Ga-ram; Shin Jae-won; Kim Hyeon-jeong; Kim A-reum; Jeong Gi-won; Ahn Ji-hun; (23 pag.)KR2018/138058; (2018); A;,
Amide – Wikipedia,
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