Synthetic Route of 14719-21-2, The chemical industry reduces the impact on the environment during synthesis 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, I believe this compound will play a more active role in future production and life.
A solution of compound 57 (50 mg, 0.08 mmol), N-propargyltrifluoroacetylamide (117 mg, 0.8 mmol), tetrakis(triphenylphosphine)-palladium(0) (18 mg, 0.02 mmol), Cul (5.9 mg, 0.03 mmol), and Et3N (48 mu?, 0.34 mmol) in anhydrous DMF (3.0 mL) was stirred at 50 C for 12 hours. The mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography to yield 7-{(5)-l-[5-methoxy-4-(3-trifluoroacetamido-l-propynyl)-2-nitrophenyl]-2,2-dimethyl-propyloxy}methyl-7-deaza-2′-deoxyguanosine 58 (50 mg, 96%). 1H NMR (400 MHz, MeOH-d4): delta 7.87 (s, 1 H, Ph-H), 7.26 (s, 1 H, Ph-H), 6.84 (s, 1 H, H-8), 6.20 (m, 1 H, H-l ‘), 5.25 (s, 1 H, Ph-CH), 4.67 (d, 1 H, J = 12.0 Hz, 7-CH2a), 4.54 (d, 1 H, J = 12.0 Hz, 7-CH2b), 4.43 (m, 1 H, H-3 ‘), 4.33 (s, 2 H, CH2), 3.95 (s, 3 H, OCH3), 3.89 (m, 1 H, H-4′), 3.70 (m, 2 H, H-5’), 2.46 (m, 1 H, H-2’a), 2.18 (m, 1 H, H-2’b), 0.86 (s, 9 H, (CH3)3).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LASERGEN, INC.; STUPI, Brian, Philip; LI, Hong; WU, Weidong; HERSH, Megan, N.; HERTZOG, David; MORRIS, Sidney, E.; METZKER, Michael, L.; WO2013/40257; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics