1520-70-3, name is Ethanesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: amides-buliding-blocks
A solution (0.05 M) of 3-cyclohexyl-1-[2(dimethylamino)-2-oxoethyl]-2-phenyl-1H- INDOLE-6-CARBOXYLIC acid (from Example 7) in CH2C12 was treated with DMAP (1.5 EQ.) and ethane sulfonamide (1.5 eq. ). EDCI (1.5 eq. ) was added and the mixture was stirred overnight. The volatiles were evaporated under reduced pressure and the residue was purified by RP-HPLC to afford the title compound (42 percent) as a solid. 1H NMR (400 MHz, DMSO-d6, 300 K) 8 1.20-1. 43 (m, 3H), 1.28 (T, J 7. 2 Hz, 3H) 1.63-1. 80 (m, 7H), 2.50-2. 58 (m, 1H, under DMSO), 2.80 (s, 3H), 2.90 (s, 3H), 3.51 (q, J 7. 2 Hz, 2H), 4.57 (s, 2H), 7.31-7. 36 (m, 2H), 7.49-7. 56 (m, 3H), 7.66 (d, J 9. 0 Hz, 1H), 7.85 (d, J 9. 0 Hz, 1H), 8.05 (s, 1H), 10.76 (br s, 1H) ; MS (ES+) m/z 496 (M+H) +.
The synthetic route of 1520-70-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA; WO2004/87714; (2004); A1;,
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