Extracurricular laboratory: Discover of H-DL-Abu-OH

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In an article, author is Guo, Yu, once mentioned the application of 2835-81-6, Formula: https://www.ambeed.com/products/2835-81-6.html, Name is H-DL-Abu-OH, molecular formula is C4H9NO2, molecular weight is 103.12, MDL number is MFCD00008093, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

Intramolecular cyclization of 2-(2,3-dihydro-1,4-benzodioxine-2-carbonyl) hydrazine-1-carbothioamide by the action of concentrated sulfuric acid gave 5-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3,4-thiadiazol-2-amine which was acylated with acid chlorides, and the resulting amides were reduced with LiAlH4 to afford the corresponding N-substituted 5-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3,4-thiadiazol-2-amine derivatives.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics