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A facile and efficient cyclization of N-alkoxy alpha-halogenoacetamides with N-(2-chloromethyl)aryl amides has been achieved for rapid access to 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-one derivatives (up to 95% yield). The intriguing features of this intermolecular cyclization include its mild reaction conditions and easy handling for scalable synthesis.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics