Application of 45120-30-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 45120-30-7, Name is H-Glu-OtBu, SMILES is O=C(O)CC[C@H](N)C(OC(C)(C)C)=O, belongs to amides-buliding-blocks compound. In a article, author is Linne, Yannick, introduce new discover of the category.
A diastereoselective [2,3] rearrangement of O-silyl N-sulfinyl N,O-ketene acetals derived from chiral N-acyl tert-butanesulfinamides was developed, giving alpha-sulfenyloxy car-boxamides with excellent enantioselectivity. Enolization and subsequent silylation of N-acyl tert-butanesulfinamides initiate this aza variant of the Mislow-Evans rearrangement, in which the chirality at the sulfur atom in the rearrangement precursors is faithfully transferred to the alpha-carbon stereocenter of the products. The Ellman sulfinamide, often used as a chiral ammonia equivalent, can serve in this rearrangement as a chiral precursor for the asymmetric synthesis of alpha-oxygen-functionalized carboxamides.
Application of 45120-30-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 45120-30-7.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics