Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.112-84-5, Name is Erucamide, SMILES is CCCCCCCC/C=CCCCCCCCCCCCC(N)=O, belongs to amides-buliding-blocks compound. In a document, author is Mohamed, Yasser M. A., introduce the new discover, Computed Properties of https://www.ambeed.com/products/112-84-5.html.
Replacing water with dimethyl sulfoxide (DMSO) completely reshapes the free-energy landscapes of solvated proteins. In DMSO, a powerful hydrogen-bond (HB) acceptor, formation of HBs between backbone NH groups and solvent is favored over HBs involving protein’s carbonyl groups. This entails a profound structural disruption of globular proteins and proteinaceous aggregates (e.g., amyloid fibrils) upon transfer to DMSO. Here, we investigate an unusual DMSO-induced conformational transition of beta(2)-amyloid fibrils from poly-L-glutamic acid (PLGA). The infrared spectra of beta(2)-PLGA dissolved in DMSO lack the typical features associated with disordered conformation that are observed when amyloid fibrils from other proteins are dispersed in DMSO. Instead, the frequency and unusual narrowness of the amide I band imply the presence of highly ordered helical structures, which is supported by complementary methods, including vibrational circular dichroism and Raman optical activity. We argue that the conformation most consistent with the spectroscopic data is that of a PLGA chain essentially lacking nonhelical segments such as bends that would provide DMSO acceptors with direct access to the backbone. A structural study of DMSO-dissolved beta(2)-PLGA by synchrotron small-angle X-ray scattering reveals the presence of long uninterrupted helices lending direct support to this hypothesis. Our study highlights the dramatic effects that solvation may have on conformational transitions of large polypeptide assemblies.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 112-84-5 is helpful to your research. Computed Properties of https://www.ambeed.com/products/112-84-5.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics