Chemistry is an experimental science, Safety of (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 114457-94-2, Name is (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid, molecular formula is C14H13N3O3, belongs to amides-buliding-blocks compound. In a document, author is Rey, J..
Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 114457-94-2, in my other articles. Safety of (S)-3-Phenyl-2-(pyrazine-2-carboxamido)propanoic acid.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics