Reference of 6000-44-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 6000-44-8, Name is Sodium 2-aminoacetate, SMILES is O=C([O-])CN.[Na+], belongs to amides-buliding-blocks compound. In a article, author is Alizadeh, Taher, introduce new discover of the category.
In search of more potent new antitubercular agents, a library of novel piperazine tethered dimeric 1,2,3-triazoles were designed by assembling 1,2,3-triazoles and piperazine in a single molecular architectural framework. The titled compounds (3a-m) were synthesized by 1,3-dipolar cycloaddition of 1,4-di(prop-2-yn-1-yl)piperazine (1) and various azides (2a-m) using click chemistry approach with good yields. All the synthesized compounds (3a-m) have been screened for their in vitro antitubercular, antifungal and antioxidant activities against their respective strains. Among them, 3b, 3d, and 3i have revealed promising antitubercular activity against Mycobacterium tuberculosis (Mtb) H37Rv with MIC 12.5 mu g/mL. Molecular docking results provided well-clustered solutions to the mode of binding for these molecules into the active site of Mtb enoyl reductase (InhA). In addition to this, most of synthesized compounds were found to have potential antifungal as well as antioxidant activity.
Reference of 6000-44-8, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 6000-44-8.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics