Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.56-86-0, Name is H-Glu-OH, SMILES is O=C(O)[C@@H](N)CCC(O)=O, belongs to amides-buliding-blocks compound. In a document, author is Jindal, Garima, introduce the new discover, COA of Formula: https://www.ambeed.com/products/56-86-0.html.
To seek more efficient and lower toxicity anticancer compounds, several imidazole combining dehydroabietylamine derivatives including organic salts (L-1-L-2) and amides (L-3-L-5) were synthesized. Their antineoplastic activity against HeLa (cervix), MCF-7 (breast), A549 (lung) and HepG2 (liver) cells and HUVECs (umbilical vein, normal cells) in vitro were evaluated by MTT assay. The results unequivocally showed that nearly all compounds had better antineoplastic activity and lower toxicity than dehydroabietylamine (L-0). For MCF-7 cells, L-2 (0.75 M) and L-5 (2.17 M) had higher anti-MCF-7 activity than L-0 and DOX. For A549 cells, L-1 (1.85 M) and L-2 (4.37 M) had higher anti-A549 activity than L-0; in particular, the IC50 value of L-1 was much lower than that of DOX. Among these investigated compounds, L-2 and L-5 had lower IC50 values (0.75 M and 2.17 M) against MCF-7 cells and lower toxicity, which suggested that they may be potential future anticancer drugs. In addition, L-1 and L-2 could suppress cancer cell proliferation by inducing apoptosis. L-1-L-5 could bind with DNA through intercalation.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 56-86-0 is helpful to your research. COA of Formula: https://www.ambeed.com/products/56-86-0.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics