The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: amides-buliding-blocks, 3144-09-0, Name is Methylsulfonamide, SMILES is CS(=O)(N)=O, in an article , author is Chen, Xuebin, once mentioned of 3144-09-0.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has become the world’s leading killer disease due to a single infectious agent which survives in the host macrophage for the indefinite period. Hence, it is necessary to enhance the efficacy of the clinically existing antitubercular agents or to discover new anti antitubercular agents. Here, we report the synthesis, characterization and antimycobacterial evaluation of protein-drug conjugates. A carrier protein, Transferrin (Tf) was covalently conjugated to isoniazid (INH) utilizing hydrazone and amide linkers. The purity of the reactions was confirmed by SDS-PAGE while conjugation was confirmed by UV-visible spectrophotometry, MALDI-TOF analysis, and FFIR spectrophotometry. The in vitro antitubercular assay result showed that the inhibitory activity of the parent drug was conserved in both the conjugates. The conjugates were effective against intracellular Mtb H37Rv and were devoid of cytotoxic effect at therapeutic concentration. (C) 2019 Elsevier Masson SAS. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 3144-09-0, you can contact me at any time and look forward to more communication. Category: amides-buliding-blocks.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics