The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 34381-71-0, Name is (S)-(-)-1-Methyl-2-pyrrolidinemethanol, SMILES is OC[C@H]1N(C)CCC1, in an article , author is Han, Pei Pei, once mentioned of 34381-71-0, Quality Control of (S)-(-)-1-Methyl-2-pyrrolidinemethanol.
Hydrogen deuterium exchange (HDX) coupled to mass spectrometry (MS) is a well-established technique employed in the field of structural MS to probe the solvent accessibility, dynamics and hydrogen bonding of backbone amides in proteins. By contrast, fast photochemical oxidation of proteins (FPOP) uses hydroxyl radicals, liberated from the photolysis of hydrogen peroxide, to covalently label solvent accessible amino acid side chains on the microsecond-millisecond timescale. Here, we use these two techniques to study the structural and dynamical differences between the protein beta(2)-microglobulin (beta(2)m) and its amyloidogenic truncation variant, Delta N6. We show that HDX and FPOP highlight structural/dynamical differences in regions of the proteins, localised to the region surrounding the N-terminal truncation. Further, we demonstrate that, with carefully optimised LC-MS conditions, FPOP data can probe solvent accessibility at the sub-amino acid level, and that these data can be interpreted meaningfully to gain more detailed understanding of the local environment and orientation of the side chains in protein structures.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics