Reference of 144978-35-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 144978-35-8, Name is 1-Boc-D-Pyroglutamic acid ethyl ester, SMILES is O=C1CC[C@H](C(OCC)=O)N1C(OC(C)(C)C)=O, belongs to amides-buliding-blocks compound. In a article, author is Rezaee, Elham, introduce new discover of the category.
Campylobacter jejuni is a pathogenic Gram-negative bacterium and a leading cause of food-borne gastroenteritis. C. jejuni produces a capsular polysaccharide (CPS)’ that contains a unique O-methyl phosphoramidate modification (MeOPN). Recently, the first step in the biosynthetic pathway for the assembly of the MeOPN modification to the CPS was elucidated. It was shown that the enzyme Cj1418 catalyzes the phosphorylation Of the amide nitrogen of L-glutamine to form L-glutamine phosphate. In this investigation, the metabolic fate of ‘,glutamine phosphate was determined. The enzyme Cj1416 catalyzes the displacement of pyrophosphate from MgCTP by L-glutamine phosphate to form CDP-L-glutamine. The enzyme Cj1417 subsequently catalyzes the hydrolysis of CDP-L-glutamine to generate cytidine diphosphoramidate and ‘,glutamate. The structures of the two novel intermediates, CDP-L-glutamine and cytidine diphosphoramidate, were confirmed by P-31 nuclear magnetic resonance spectroscopy and mass spectrometry. It is proposed that the enzyme Cj1416 be named CTP:phosphoglutamine cytidylyltransferase and that the enzyme Cj1417 be named gamma-glutamyl-CDP-amidate hydrolase.
Reference of 144978-35-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 144978-35-8.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics