Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 52-89-1, Name is H-Cys-OH.HCl, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Hock, Andreas, Recommanded Product: 52-89-1.
The adipokine, apelin has many biological functions but its activity is curtailed by rapid plasma degradation. Fatty acid derived apelin analogues represent a new and exciting avenue for the treatment of obesity-diabetes. This study explores four novel fatty acid modified apelin-13 analogues, namely, (Lys(8)GluPAL)apelin-13 amide, pGlu(Lys(8)GluPAL)apelin-13 amide, Lys(8)GluPAL(Tyr(13))apelin-13 and Lys(8)GluPAL(Val(73))apelin-13. Fatty acid modification extended the half-life of native apelin-13 to >24 h in vitro. pGlu(Lys(8)GluPAL)apelin-13 amide was the most potent insulinotropic analogue in BRIN-BD11 cells and isolated islets with maximal stimulatory effects of up to 2.7-fold (p < .001). (Lys(8)GluPAL) apelin-13 amide (1.9-fold) and Lys(8)GluPAL(Tyr(13))apelin-13 (1.7-fold) were less effective, whereas Lys(8)GluPAL(Val(13))apelin-13 had an inhibitory effect on insulin secretion. Similarly, pGlu(Lys(8)GluPAL) apelin-13 amide was most potent in increasing beta-cell intracellular Ca2+ concentrations (1.8-fold, p < .001) and increasing glucose uptake in 3T3-L1 adipocytes (2.3-fold, p < .01). Persistent biological action was observed with both pGlu(Lys(8)GluPAL)apelin-13 amide and (Lys(8)GluPAL)apelin-13 amide significantly reducing blood glucose (39-43%, p < .01) and enhancing insulin secretion (43-56%, p < .001) during glucose tolerance tests in diet-induced obese mice. pGlu(Lys8GluPAL)apelin-13 amide and (Lys(8)GluPAL)apelin-13 amide also inhibited feeding (28-40%, p < .001), whereas Lys(8)GluPAL(Val(13)) apelin-13 increased food intake (8%, p < .05) in mice. These data indicate that novel enzymatically stable analogues of apelin-13 may be suitable for future development as therapeutic agents for obesity-diabetes. (C) 2017 Elsevier Inc. All rights reserved. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 52-89-1, in my other articles. Recommanded Product: 52-89-1.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics