The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 6313-33-3, Name is Formimidamide hydrochloride, SMILES is N=CN.[H]Cl, in an article , author is Tahtat, Djamel, once mentioned of 6313-33-3, Formula: https://www.ambeed.com/products/6313-33-3.html.
The usefulness of higher-order structural information provided by hydrogen/deuterium exchange-mass spectrometry (H/DX-MS) for the structural impact analyses of chemical and post-translational antibody modifications has been demonstrated in various studies. However, the structure-function assessment for protein drugs in biopharmaceutical research and development is often impeded by the relatively low-abundance (below 5%) of critical quality attributes or by overlapping effects of modifications, such as glycosylation, with chemical amino acid modifications; e.g., oxidation or deamidation. We present results demonstrating the applicability of the H/DX-MS technique to monitor conformational changes of specific Fc glycosylation variants produced by in vitro glyco-engineering technology. A trend towards less H/DX in Fc C gamma 2 domain segments correlating with larger glycan structures could be confirmed. Furthermore, significant deuterium uptake differences and corresponding binding properties to Fc receptors (as monitored by SPR) between alpha-2,3- and alpha-2,6-sialylated Fc glycosylation variants were verified at sensitive levels.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics