Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.637-01-4, Name is N1,N1,N4,N4-Tetramethylbenzene-1,4-diamine dihydrochloride, SMILES is CN(C)C1=CC=C(N(C)C)C=C1.[H]Cl.[H]Cl, belongs to amides-buliding-blocks compound. In a document, author is Soberanes, Yedith, introduce the new discover, Safety of N1,N1,N4,N4-Tetramethylbenzene-1,4-diamine dihydrochloride.
Resiquimod is an immunopotent toll-like receptor 7/8 agonist with antitumor activity. Despite being potent against skin cancers, it is poorly tolerated systemically due to toxicity. Integrating resiquimod into nanoparticles presents an avenue to circumvent the toxicity problem. Herein, the preparation of degradable nanoparticles with covalently bound resiquimod and their systemic application in cancer immunotherapy is reported. Dispersion in water of amphiphilic constructs integrating resiquimod covalently bound via degradable amide or ester linkages yields immune-activating nanoparticles. The degradable agonist-nanoparticle bonds allow the release of resiquimod from the carrier nanoparticles. In vitro assays with antigen presenting cells demonstrate that the nanoparticles retain the immunostimulatory activity of resiquimod. Systemic administration of the nanoparticles and checkpoint blockade (aPD-1) to a breast cancer mouse model with multiple established tumors triggers antitumor activity evidenced by suppressed tumor growth and enhanced CD8(+) T-cell infiltration. Nanoparticles with ester links, which hydrolyze more readily, yield a stronger immune response with 75% of tumors eliminated when combined with aPD-1. The reduced tumor growth and the presence of activated CD8(+) T-cells across multiple tumors suggest the potential for treating metastatic cancer.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 637-01-4 is helpful to your research. Safety of N1,N1,N4,N4-Tetramethylbenzene-1,4-diamine dihydrochloride.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics