Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Xu, Xiong, once mentioned the application of 150-25-4, Name is 2-(Bis(2-hydroxyethyl)amino)acetic acid, molecular formula is C6H13NO4, molecular weight is 163.17, MDL number is MFCD00004295, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, SDS of cas: 150-25-4.
Transition metal-catalyzed enantioselective Sonogashira-type oxidative C(sp(3))-C(sp) coupling of unactivated C(sp(3))-H bonds with terminal alkynes has remained a prominent challenge. The difficulties mainly stem from the regiocontrol in unactivated C(sp(3))-H bond functionalization and the inhibition of readily occurring Glaser homocoupling of terminal alkynes. Here, we report a copper/chiral cinchona alkaloid-based N,N,P-ligand catalyst for asymmetric oxidative cross-coupling of unactivated C(sp(3))-H bonds with terminal alkynes in a highly regio-, chemo-, and enantioselective manner. The use of N-fluoroamide as a mild oxidant is essential to site-selectively generate alkyl radical species while efficiently avoiding Glaser homocoupling. This reaction accommodates a range of (hetero)aryl and alkyl alkynes; (hetero)benzylic and propargylic C(sp(3))-H bonds are all applicable. This process allows expedient access to chiral alkynyl amides/aldehydes. More importantly, it also provides a versatile tool for the construction of chiral C(sp(3))-C(sp), C(sp(3))-C(sp(2)), and C(sp(3))-C (sp(3)) bonds when allied with follow-up transformations.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics