Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Computed Properties of https://www.ambeed.com/products/104-63-2.html, 104-63-2, Name is 2-(Benzylamino)ethanol, molecular formula is C9H13NO, belongs to amides-buliding-blocks compound. In a document, author is Yang Wei-Mei, introduce the new discover.
Herein, we report the synthesis and biological characterization of the new peptide psi RGDechi as the first step toward novel targeted theranostics in melanoma. This pseudopeptide is designed from our previously reported RGDechi peptide, known to bind selectively alpha(v)beta(3) integrin, and differs for a modified amide bond at the main protease cleavage site. This chemical modification drastically reduces the enzymatic degradation in serum, compared to its parental peptide, resulting in an overall magnification of the biological activity on a highly expressing alpha(v)beta(3) human metastatic melanoma cell line. Selective inhibition of cell adhesion, wound healing, and invasion are demonstrated; near infrared fluorescent t psi RGDechi derivative is able to detect alpha(v)beta(3) integrin in human melanoma xenografts in a selective fashion. More, molecular docking studies confirm that psi RGDechi recognizes the receptor similarly to RGDechi. All these findings pave the way for the future employment of this novel peptide as promising targeting probe and therapeutic agent in melanoma disease.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 104-63-2. Computed Properties of https://www.ambeed.com/products/104-63-2.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics