Electric Literature of 56-84-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 56-84-8, Name is H-Asp-OH, SMILES is N[C@@H](CC(O)=O)C(O)=O, belongs to amides-buliding-blocks compound. In a article, author is Sasaki, Yoshikazu, introduce new discover of the category.
Selective cyanation of aryl halides was achieved with CO2 and NH3 as the only sources of carbon and nitrogen, respectively. In the presence of Cu catalysts under low pressure (3 atm), a variety of aromatic iodides and bromides were transformed to the desired nitrile products without the use of toxic metal cyanides. Notably, olefins, esters, amides, alcohols, and amino groups were tolerated. Mechanistic studies suggest that Cu(III)-aryl insertion by isocyanate intermediates is involved. [C-13,N-15]-labeled nitriles were conveniently accessible from the respective isotope-labeled CO2 and NH3 via this methodology.
Electric Literature of 56-84-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 56-84-8.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics