Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wang, Lizhen, once mentioned the application of 62965-35-9, Name is Boc-Tle-OH, molecular formula is C11H21NO4, molecular weight is 231.2887, MDL number is MFCD00065574, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of Boc-Tle-OH.
This study reports the metal-free formylation of amides using carbon dioxide under ambient conditions. An abnormal N-heterocyclic carbene (aNHC) acts as an efficient catalyst for the formylation of amides in the presence of hydrosilane at room temperature. This methodology enables the formation of a C-N bond and can be utilized in building up core moieties of two natural products having strong larvicidal activity such as alatamide and lansiumamide A. A preliminary mechanistic picture for this transformation has been proposed through isolation of reaction byproduct (confirmed by single crystal X-ray study) as well as by characterizing intermediates with spectroscopy.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics