In an article, author is Ghiazza, Clement, once mentioned the application of 62009-47-6, Recommanded Product: 62009-47-6, Name is 2-Aminomalonamide, molecular formula is C3H7N3O2, molecular weight is 117.11, MDL number is MFCD00015932, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
The C-C coupling reaction of N-electron withdrawing group (EWG) protected amides with coupling partners is one of the most important methods for C-C bond formation at the a-position of amides to directly give a-substituted amides. Of the four reactions, namely, the reaction via the generation of carbanion with an electrophile, that via the generation of carbon radical with a radical donor, that via the generation of iminium ion species with a nucleophile (oxidative coupling reaction), and that using a transition metal carbenoid, the oxidative coupling reaction presents a challenge although the reaction products are very useful for the transformation of a wide range of nitrogen-containing derivatives. In this review, recent developments in the oxidative coupling reaction of N-EWG protected amides with nucleophiles are summarized with focus on the reaction using a transition metal, the transition-metal-free reaction, the enantioselective reaction using a chiral catalysts, and the organocatalyzed oxidative coupling reaction. (C) 2017 Elsevier Ltd. All rights reserved.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics