Synthetic Route of 600-21-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 600-21-5, Name is H-N-Me-DL-Ala-OH, SMILES is CC(NC)C(O)=O, belongs to amides-buliding-blocks compound. In a article, author is Bonanomi, Giuliano, introduce new discover of the category.
BackgroundPancreatic ductal adenocarcinoma (PDA) is a fatal disease with very poor prognosis. Development of sensitive and noninvasive methods to monitor tumor progression in PDA is a critical and unmet need. Magnetic resonance imaging (MRI) can noninvasively provide information regarding underlying pathophysiological processes such as necrosis, inflammatory changes and fibrotic tissue deposition.MethodsA genetically engineered KPC mouse model that recapitulates human PDA was used to characterize disease progression. MR measures of T-1 and T-2 relaxation times, magnetization transfer ratio (MTR), diffusion and chemical exchange saturation transfer were compared in two separate phases i.e. slow and rapid growth phase of tumor. Fibrotic tissue accumulation was assessed histologically using Masson’s trichrome staining. Pearson correlation coefficient (r) was computed to assess the relationship between the fibrotic tissue accumulation and different MR parameters.ResultsThere was a negative correlation between amide proton transfer signal intensity and tumor volume (r=-0.63, p=0.003) in the slow growth phase of the tumor development. In the terminal stage of rapid growth phase of the tumor development MTR was strongly correlated with tumor volume (r=0.62, p=0.008). Finally, MTR was significantly correlated with % fibrosis (r=0.87; p<0.01), followed by moderate correlation between tumor volume (r=0.42); T-1 (r=-0.61), T-2 (r=-0.61) and accumulation of fibrotic tissue.ConclusionsHere we demonstrated, using multi-parametric MRI (mp-MRI), that MRI parameters changed with tumor progression in a mouse model of PDA. Use of mp-MRI may have the potential to monitor the dynamic changes of tumor microenvironment with increase in tumor size in the transgenic KPC mouse model of pancreatic tumor. Synthetic Route of 600-21-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 600-21-5.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics