Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 13404-22-3, Name is H-Ala-OtBu.HCl, SMILES is C[C@H](N)C(OC(C)(C)C)=O.[H]Cl, in an article , author is Priscilla, J., once mentioned of 13404-22-3, Application In Synthesis of H-Ala-OtBu.HCl.
A series of 7-O-amide hesperetin derivatives were subjected to multi-target biological evaluation of anti-Alzheimer’s disease. Most of the compounds showed good in vitro inhibitory activity against cholinesterase, of which compound 7c (7-O-(4-(morpholinoethyl)-acetamide) hesperetin) was the most effective anti-eqBuChE derivative (IC50 = 0.28 +/- 0.05 mu M) and exerted neuropmtective effects. Further biological evaluation found that compounds 4d, 4e and 7c showed strong antioxidant, anti-A beta self-aggregation and anti-neuroinflammatory activities. Compound 7c could inhibit the expression of iNOS and COX-2 proteins and prevent LPS-induced inflammatory response in BV2 cells. In addition, compound 7c could chelate biometal ions such as Cu2+ and Zn2+. In the vivo study, the MWM test confirmed that compound 7c could improve the cognitive impairment caused by scopolamine. In summary, the above studies have shown that the optimized compound 7c has great development potential as MTDL for the treatment of AD.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 13404-22-3, you can contact me at any time and look forward to more communication. Application In Synthesis of H-Ala-OtBu.HCl.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics