Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 3184-13-2, Name is H-Orn-OH Hydrochloride, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Abrams, Geoffrey D., SDS of cas: 3184-13-2.
The unique electronic reactivity of imidates has been recently exploited for the syntheses of diverse classes of N-heterocycles via C-N annulation reactions under acid/base/metal-catalyzed/radical-mediated reaction conditions. As opposed to amides, the imidate functionality provides both electrophilic and nucleophilic centers and eventually enhances its versatility as an organic synthon. In general, imidate motifs act as the soft nucleophiles that coordinate with transition metals to form stable 5-membered metallacycles to activate the proximal C-H bonds followed by annulation reactions to afford the desired N-heterocycles. The imidate precursor also generates in situ nitrogen radicals under suitable conditions to form C-N bonds via 1,5-HAT. This review highlights the recent application of imidates as building blocks for the synthesis of saturated and un-saturated N-heterocycles like oxazolines, oxazines, quinazolines, isoquinolines, imidazoles, and triazoles among others. Different reaction conditions, coupling partners, and imidate substrates reported in the literature have been addressed herein for the nitrogen-containing mono-, bi- and tricyclic ring systems.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3184-13-2, in my other articles. SDS of cas: 3184-13-2.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics