Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 1243308-37-3, 1243308-37-3, Name is Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride, molecular formula is C9H10Cl2N2O3, belongs to amides-buliding-blocks compound. In a document, author is Yi, Y., introduce the new discover.
The present study evaluates the effect of molecular mobility and molecular interactions in the physical stability of rivaroxaban (RIV) – soluplus (R) (SOL) amorphous solid dispersions (ASDs). Initially, the use of Adam-Gibbs approach revealed that RIV’s molecular mobility (below its glass transition temperature) is significantly reduced in the presence of SOL, while the use of ATR-FTIR spectroscopy showed the formation of hydrogen bonds (HBs) between the two ASD components, indicating that these two mechanisms can be considered as responsible for system’s physical stability. Contrary to previously published reports, the utilization of ATR-FTIR spectroscopy in the present study was able to clarify, for the first time, the type of intermolecular interactions formed within the examined ASD system, while the presence of a separate drug-rich amorphous phase (significantly increasing as the content of the drug increases) was also identified. Furthermore, in order to gain an insight into the intermolecular interactions responsible for drug’s amorphous phase separation, molecular dynamics (MD) simulation models were utilized as realistic representations of the actual systems. Analysis of the obtained trajectories showed that the formation of strong intermolecular HBs between RIV’s secondary amide proton and its three carbonyl oxygens (originating from the oxazolidone, oxomorpholin and carboxamide part of the drug molecule) as well as the significant reduction of the available HB acceptors in SOL due to copolymer’s chain shrinkage, were responsible for the formation of a separate drug-rich amorphous phase within the ASD.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1243308-37-3. Product Details of 1243308-37-3.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics