Related Products of 52328-05-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 52328-05-9, Name is O-Methylisourea hemisulfate, SMILES is N=C(N)OC.N=C(N)OC.O=S(O)(O)=O, belongs to amides-buliding-blocks compound. In a article, author is Kim, Yun Ki, introduce new discover of the category.
A divergent strategy for the asymmetric syntheses of D-fagomine and three of its diastereoisomers has been developed. The diastereoselective conjugate addition of an enantiopure lithium amide to an alpha,beta-unsaturated ester was used as the key step to install the correct configuration required for the C(5)stereogenic centre within the targets. In situ enolate oxidation generated the corresponding anti-alpha-hydroxy-beta-amino ester, which possessed the correct configuration required for the C(4)-stereogenic centre within both D-fagomine and D-3-epi-fagomine. Subsequent epimerisation of this key anti-alpha-hydroxy-beta-amino ester upon oxidation and diastereoselective reduction gave the corresponding syn-alpha-hydroxy-fiamino ester, which possessed the correct configuration required for the C(4)-stereogenic centre within both D-4-epi-fagomine and D-5-epi-fagomine. Elaboration of both alpha-hydroxy-beta-amino esters upon reduction to the corresponding aldehydes followed by aldol reaction generated the requisite C(3)stereogenic centres within the target compounds, then cyclisation and deprotection gave the enantiopure iminosugars in good overall yields, as single diastereoisomers (>99:1 dr). (C) 2018 Elsevier Ltd. All rights reserved.
Related Products of 52328-05-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 52328-05-9 is helpful to your research.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics