Electric Literature of 140-95-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 140-95-4, Name is N,N’-Bis(hydroxymethyl)urea, SMILES is O=C(NCO)NCO, belongs to amides-buliding-blocks compound. In a article, author is Chemin, Jean, introduce new discover of the category.
The potential role of nine thiols as chemical protectors against the toxicity of paracetamol (acetaminophen, APAP) and its meta analogue N-acetyl-m-aminophenol (AMAP) was investigated using the density functional theory. They are glutathione (GSH), N-acetylcysteine (NAC), NAC amide (NACA), tiopronine (TPR), dihydrolipoic acid (DHL), 6-mercaptopurine (6MP), 6-thioguanine (6TG), 2,3-dimercaprol (DMC), and D-penicillamine (PNA). The investigation was focused on the toxic effects derived from protein arylation at cysteine residues, induced by the quinone imines formed from APAP and AMAP. On the basis of both thermochemical and kinetic considerations, with the exceptions of 6MP and 6TG, the investigated thiols may be useful in protecting the chemical integrity of cysteine residues in proteins from arylation by quinone imines. The order of efficiency for that purpose is predicted to be NAC > GSH > TPR > NACA > DMC > DHL. However, considering physicochemical properties that may affect bioavailability and cell permeability, DHL seems to be the best prospect to be orally supplied.
Electric Literature of 140-95-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 140-95-4.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics