Chemistry is an experimental science, Computed Properties of https://www.ambeed.com/products/138-41-0.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 138-41-0, Name is Carzenide, molecular formula is C7H7NO4S, belongs to amides-buliding-blocks compound. In a document, author is Zhang, Li.
Aim: Synthesis and evaluation of an entirely S-protected chitosan as mucoadhesive excipient for vaginal drug delivery. Methods: N-acetyl-cysteine was linked to 6-mercaptonicotinamide via disulphide exchange reaction. The obtained ligand, NAC-6-MNA, was subsequently attached to chitosan by carbodiimide mediated amide bond formation in two concentrations. The synthesized S-protected chitosan was chemically characterized and mucoadhesive properties and stability against oxidation were investigated. Moreover, metronidazole tablets comprising the S-protected chitosan were evaluated regarding water uptake capacity, disintegration behaviour, residence time on vaginal mucosa, release of the encapsulated drug and antimicrobial activity. Results: S-protected chitosan displayed 160 +/- 19 (CS-MNA-160) and 320 +/- 38 (CS-MNA-320) mu mol of ligand per gram of polymer. At pH 4.2, CS-MNA-160 and CS-MNA-320 showed 5.2-fold and 6.2-fold increase in mucus viscosity in comparison to unmodified chitosan (One-way ANOVA, p < .001), whereas, 9.9-fold (CS-MNA-160) and 15.6-fold (CS-MNA-320) (One-way ANOVA, p < .001) increase in viscosity was measured at pH 6. The S-protected chitosan remained stable against oxidation in presence of 0.5% v/v hydrogen peroxide. Metronidazole tablets consisting in S-protected chitosan showed prolonged residence time on vaginal mucosa and improved water uptake capacity and disintegration time in comparison to tablets consisting of unmodified chitosan. Moreover, CS-MNA-320 metronidazole tablets displayed prolonged drug release and antimicrobial activity. Conclusions: On the basis of the achieved results, entirely S-protected chitosan represents a promising excipient for the development of metronidazole vaginal tablets. (c) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 138-41-0, in my other articles. Computed Properties of https://www.ambeed.com/products/138-41-0.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics