Synthetic Route of 2491-20-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2491-20-5, Name is H-Ala-OMe.HCl, SMILES is N[C@@H](C)C(OC)=O.[H]Cl, belongs to amides-buliding-blocks compound. In a article, author is Zhang, Lei, introduce new discover of the category.
The enzyme Delta(24)-dehydrocholesterol reductase (DHCR24) catalyzes the reduction of the Delta(24)-double bond in the side chain of cholesterol precursors. Recent biochemical investigations fuel the hope that inhibition of DHCR24, resulting in an accumulation of desmosterol, can open new therapeutic options for treating hepatitis C virus infections, certain forms of cancer and atherosclerosis. In turn, there is a high need for selective, potent and non-toxic inhibitors of DHCR24. Previous reports as well as our re-evaluation showed that established DHCR24 inhibitors are not suitable for this purpose. Based on the lathosterol-derived amide MGI-21 (IC50 823 nM for inhibition of overall cholesterol biosynthesis in HL 60 cells) we performed a systematic variation of the side chain functionality and identified the steroidal 3,22-diols 29 and 30, as well as several esters thereof, as extremely potent (IC50 < 5 nM), selective, and non-toxic DHCR24 inhibitors. In mice, diester 27 (SH-42) led to a significant increase in plasma desmosterol levels. The new inhibitors described here are valuable tools for investigating the therapeutic potential of DHCR24 inhibition. (C) 2017 Elsevier Masson SAS. All rights reserved. Synthetic Route of 2491-20-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2491-20-5.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics