Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 52328-05-9, Name is O-Methylisourea hemisulfate, molecular formula is C4H14N4O6S, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Price, Neil P. J., once mentioned the new application about 52328-05-9, Recommanded Product: 52328-05-9.
The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, halogen and hydroxyl substituents, which are amenable for further synthetic elaborations, are well tolerated. Moreover, the present synthetic route could be readily scaled up to gram quantity without difficulty. The mechanism possibly involves nucleophilic addition to the nitrile function, forming an imine intermediate followed by an intramolecular addition to the amide and dehydration to the quinazoline ring.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 52328-05-9. The above is the message from the blog manager. Recommanded Product: 52328-05-9.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics