Reference of 71-44-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 71-44-3, Name is Spermine, SMILES is NCCCNCCCCNCCCN, belongs to amides-buliding-blocks compound. In a article, author is Gotthelf, Garret, introduce new discover of the category.
The design, synthesis, and biological evaluation of stilbene-based novobiocin analogues is reported. Replacement of the biaryl amide side chain with a triazole side chain produced compounds that exhibited good antiproliferative activities. Heat shock protein 90 (Hsp90) inhibition was observed when N-methylpiperidine was replaced with acyclic tertiary amines on the stilbene analogues that also contain a triazole-derived side chain. These studies revealed that approximate to 24 angstrom is the optimal length for compounds that exhibit good antiproliferative activity as a result of Hsp90 inhibition.
Reference of 71-44-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 71-44-3 is helpful to your research.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics