In an article, author is Battista, Natalia, once mentioned the application of 6600-40-4, Formula: https://www.ambeed.com/products/6600-40-4.html, Name is (S)-2-Aminopentanoic acid, molecular formula is C5H11NO2, molecular weight is 117.15, MDL number is MFCD00064421, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA), which integrates inputs from three major types of GPCRs. Despite its wide usage as a pharmaceutical inhibitor of PKA, it was unclear whether PKI only inhibits PKA activity. Here, the effects of PKI on 55 mouse kinases were tested in in vitro assays. We found that in addition to inhibiting PKA activity, both PKI (6-22) amide and full-length PKI alpha facilitated the activation of multiple isoforms of protein kinase C (PKC), albeit at much higher concentrations than necessary to inhibit PKA. Thus, our results call for appropriate interpretation of experimental results using PKI as a pharmaceutical agent. Furthermore, our study lays the foundation to explore the potential functions of PKI in regulating PKC activity and in coordinating PKC and PKA activities.
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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics