Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Park, Sang Ho, once mentioned the application of 57-13-6, Name is Urea, molecular formula is CH4N2O, molecular weight is 60.0553, MDL number is MFCD00008022, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Formula: https://www.ambeed.com/products/57-13-6.html.
The first synthesis of isoxazole-4-carboxylic acid derivatives by domino isoxazole-isoxazole isomerization is reported. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxy-/5-aminoisoxazoles (dioxane, 105 degrees C) leads to the formation of isoxazole-4-carboxylic esters and amides in good yields. 4-Formyl-5-methoxyisoxazoles give methyl oxazole-4-carboxylates under the same reaction conditions. Fe(II)-catalyzed isomerization of 4-acyl-5-methoxyisoxazoles under milder conditions (MeCN, 50 degrees C) allows the preparation of transient 2-acyl-2-(methoxycarbonyl)-2H-azirines. The azirines isomerize quantitatively either into isoxazoles under catalytic conditions (dioxane, 105 degrees C) or into oxazoles under noncatalytic thermolysis (o-dichlorobenzene, 170 degrees C). The mechanism of the isomerization and dependence of the reaction routes on substituents at starting isoxazole core and reaction conditions are discussed on the basis of DFT calculations.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 57-13-6, Formula: https://www.ambeed.com/products/57-13-6.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics