In an article, author is Deng, Zhiqiang, once mentioned the application of 52-52-8, Name is 1-Aminocyclopentanecarboxylic acid, molecular formula is C6H11NO2, molecular weight is 129.157, MDL number is MFCD00001381, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Application In Synthesis of 1-Aminocyclopentanecarboxylic acid.
Carbamazepine (CBZ) is considered to be the preferred drug for fractional seizures and may also use in the prevention of primary generalized tonic-clonic seizures. The chelates of CBZ with Fe(III), Co(II), Ni(II), Cu(II), and Zr(IV) were designed and characterized on the basis of elemental analysis, FT-IR, 1H NMR, UV-visible, mass spectra, thermal analysis (TG, DTG, and DTA), molar conductivity, and magnetic moment. IR spectra emphasize that CBZ acts as a neutral bidentate ligand with metal ions through amide oxygen and amino nitrogen. UV-visible spectra and magnetic moment demonstrate that all chelates have geometric octahedral structures. Complexes thermal behavior is systematically analyzed employing TG and DTA technicality. TG findings signalize that water molecules (hydrated and coordinated) are extracted the first and second phases, while CBZ ligand is splitted in the second and subsequent steps. From the DTA curves, the obtained data reflect that the degradation processes are endothermic or exothermic peaks. Assorted thermodynamic factors are calculated, and the results are explicated. Antimicrobial activity was examined against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti-fungal efficacy of the compounds has been tested. The Co(II) complex was highly significant against the antifungal Candida albicans and significantly against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 52-52-8, Application In Synthesis of 1-Aminocyclopentanecarboxylic acid.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics