Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 142-25-6, Name is N1,N1,N2-Trimethylethane-1,2-diamine, SMILES is CNCCN(C)C, belongs to amides-buliding-blocks compound. In a document, author is Asghari, Sakineh, introduce the new discover, SDS of cas: 142-25-6.
Scaffolds of 2-acylamino-1,3,4-oxadiazole have been recently developed as transglycosylase inhibitors against MRSA. In the present study, structure-activity relationships of new derivatives of 2-acylamino-1,3,4-oxadiazole were explored with focus on the substitution of the aromatic rings. The in vitro antibacterial activity of these compounds against MRSA strain was evaluated using agar disc diffusion method. These inhibitors have an amide linker between 1,3,4-oxadiazole ring and the aromatic ring B. The role of this linker on the bioactivity of the compounds was also studied. The results showed promising series of 2–aminophosphonate-1,3,4-oxadiazole as inhibitors for MRSA strain. Both series revealed two structural features which appear to be essential for anti-MRSA activities, the first one is the incorporation of two electron-withdrawing groups at meta- and para- positions within aromatic ring B which contributed to a higher activity against MRSA strain. The second is the new -aminophosphonate linker serving as bio-isosteric analogue of the corresponding amide linker and giving comparable results with the amide derivatives. [GRAPHICS]
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 142-25-6 is helpful to your research. SDS of cas: 142-25-6.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics