Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 102195-79-9, Name is (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate, SMILES is O=C(N1[C@H](C(OC)=O)C[C@H](O)C1)OC(C)(C)C, in an article , author is Samai, S., once mentioned of 102195-79-9, Application In Synthesis of (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate.
Upper Critical Solution Temperature Layer-by-Layer Films of Polyamino acid-Based Micelles with Rapid, On-Demand Release Capability
Here, we report on upper critical solution temperature (UCST)-type polyamino acid-based block copolymer assembled in a layer-by-layer system with a natural polyphenol. The UCST-type block copolymer, polyvinylpyrrolidone-b-polyureido(ornithine-co-lysine) (PVP-b-PUOL), was synthesized via ring opening polymerization followed by postpolymerization functionalization with ureido groups. PVP-b-PUOL exhibited UCST behavior that was controlled by both molecular weight and ornithine-to-lysine ratio. Importantly, PVP-b-PUOL with a UCST of 33 degrees C assembled into block copolymer micelles below UCST and dissociated above UCST, yet this behavior was not repeatable in solution due to beta-sheet formation and large-scale aggregation. To overcome this limitation, UCST micelles (UCSTMs) were deposited within layer-by-layer (LbL) films via hydrogen bonding with tannic acid (TA). Significantly, the assembled TA/UCSTM films stabilized the micelles from desorption while maintaining their morphology and prevented beta-sheet formation even after continuous exposure to 40 degrees C for 7 days. Moreover, these films demonstrated repeatable swelling-deswelling for up to five temperature cycles from 25 to 40 degrees C. The thermo-switchable hydrophobicity of micellar cores was used for trapping of a model active molecule, pyrene, and its on-off temperature-controlled release, demonstrating the potential of TA/UCSTM films for controlled delivery of active molecules.
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