Electric Literature of 71-00-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 71-00-1, Name is H-His-OH, SMILES is N[C@@H](CC1=CNC=N1)C(O)=O, belongs to amides-buliding-blocks compound. In a article, author is Garzinsky, David, introduce new discover of the category.
Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol. (C) 2017 Elsevier Ltd. All rights reserved.
Electric Literature of 71-00-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 71-00-1.