Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 84358-13-4, 84358-13-4, Name is Boc-Inp-OH, SMILES is CC(OC(N1CCC(C(O)=O)CC1)=O)(C)C, belongs to amides-buliding-blocks compound. In a document, author is Kabirb, Sk Faisal, introduce the new discover.
Convergent synthesis of 4,6-unsubstituted 5-acy1-2aminodihydropyrimidines using Weinreb amide
A method of convergent synthesis of novel 4,6-unsubstituted 5-acyl-2-aminodihydropyrimidines 7 is developed. The synthetic intermediate of 7, 4,6-unsubstituted 2-aminodihydropyrimidines 9 having a Weinreb amide at the 5-position, is prepared by the sequential Staudinger/aza-Wittig/cyclization reactions of (E)-tert-buty1{3-azido-2-Imethoxy(methyl)carbamoyljallyl}carbamate (E)-10. The transformation of the Weinreb amide of 9 to an acyl group proceeds smoothly by a substitution reaction using aryllithiums or alkyllithiums in the presence of a catalytic amount of BF3 etherate, affording 7 in good to high yield. The N-protecting group of 7 can be easily removed to obtain N-unsubstituted 2-amino5-acyldihydropyrimidines 8, and the derivatives are observed as a single isomer in H-1 NMR spectroscopy. All dihydropyrimidines in this study were hitherto unavailable and difficult to synthesize by conventional methods. (C) 2017 Elsevier Ltd. All rights reserved.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 84358-13-4. Product Details of 84358-13-4.