In an article, author is Glachet, Thomas, once mentioned the application of 1243308-37-3, Name is Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride, molecular formula is C9H10Cl2N2O3, molecular weight is 265.09, MDL number is MFCD02625495, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride.
Catalytic intermolecular aldol reactions of transient amide enolates in domino Michael/aldol reactions of nitroalkanes, acrylamides, and aldehydes
Three-component reactions of nitroalkanes, acrylamides, and aldehydes by using a catalytic amount of KOH in DMSO gave beta ‘-hydroxy-gamma-nitro amides. Mechanistic studies suggested that the reactions proceeded by domino Michael/aldol reactions. The highly nucleophilic nature of transient amide enolates that were formed by Michael addition of nitronate anions to acrylamides in DMSO enabled the realization of catalytic intermolecular aldol reactions of amide enolates in the presence of acidic nitroalkanes.
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